This research is aimed at examine and analyze Inflation Influence, Exchange Rate, World Oil Price, DER & ROA on Stock Price. The research data is the annual data for the 5 year observation period (2012 to 2016). The sampling method used is purposive sampling. Of the population of 7 oil and gas companies listed on the Indonesia Stock Exchange, 6 oil and gas companies listed on the Indonesia Stock Exchange meet the criteria as sample. The method of analysis used in this research is panel data regression. The results showed Inflation, Exchange rate, world oil prices, DER & ROA simultaneously significantly influence the Stock Price. Partially Inflation and Return on Asset (ROA) have a negative and significant effect on Stock Price, while Exchange Rate and Debt to Equity Ratio (DER) have no effect on Stock Price. And for World Oil Prices have a positive and significant effect on Stock Price. World Oil Price is the biggest significant variable on Stock Price.